CERI Research Focus Areas Microbiome
04

African
Microbiome
Research

Microbiome africanmicrobiomeproject.org

Studying microbial ecosystems across human, environmental, and agricultural settings to understand how microbes influence health, immunity, and disease — closing critical knowledge gaps in globally underrepresented African microbiomes.

Microbial Diversity
Human Microbiome
Environmental Microbiome
Infection Risk
Reproductive Health
African Microbiome Dashboard
Research Active
Human Microbiome
Environmental
Agricultural
Reproductive
Nutrition
Immunity
Gut Microbiome Diversity
87%
Vaginal Microbiome
79%
Environmental Sampling
65%
10K+
Samples Collected
8+
African Countries
60+
Publications
// Research Focus

What the Team
Investigates

FOCUS · 01
Human Microbiome Diversity

Mapping the diversity of gut, vaginal, oral, and skin microbiomes across African populations to build a continent-specific reference resource.

16S rRNA Metagenomics Diversity
FOCUS · 02
Microbiome & Infection Risk

Investigating how microbial community composition influences susceptibility to infectious diseases including HIV, TB, and sexually transmitted infections.

HIV Risk STIs TB
FOCUS · 03
Reproductive Health

Studying the vaginal microbiome and its role in reproductive health outcomes, preterm birth, fertility, and susceptibility to gynaecological infections.

Vaginal Microbiome Preterm Birth Fertility
FOCUS · 04
Nutrition & Gut Health

Examining how diet, food systems, and nutritional status shape gut microbiome composition and influence immunity and child development in Africa.

Gut Health Diet Child Health
FOCUS · 05
Environmental Microbiomes

Sampling microbial ecosystems in water, soil, and agricultural environments to understand transmission routes and environmental health risks.

Water Soil One Health
FOCUS · 06
Diagnostics & Therapeutics

Developing microbiome-based diagnostic tools and investigating microbiome modulation as a therapeutic strategy suited to African health systems.

Biomarkers Probiotics Diagnostics
// Research Workflow

From Field
to Discovery

STEP · 01
Field Collection

Human, environmental, and agricultural samples collected across diverse African settings through community-based fieldwork and clinical partnerships.

STEP · 02
Lab Processing

DNA extraction, library preparation, and 16S rRNA or whole metagenome sequencing to characterise microbial community composition.

STEP · 03
Metagenomic Analysis

Bioinformatic pipelines for taxonomic classification, functional annotation, and diversity analysis of microbial communities at scale.

STEP · 04
Integrated Analysis

Linking microbiome data with clinical, immunological, nutritional, and environmental metadata to identify health-relevant associations.

STEP · 05
Clinical Translation

Developing microbiome-informed diagnostics, therapeutic targets, and public health recommendations for African populations.

// Research Themes

Key Areas of
Investigation

Gut Microbiome Composition, Diversity & Health Outcomes
Characterising gut microbiome diversity across African populations and linking community composition to health, immunity, and disease outcomes.
Active
Vaginal Microbiome HIV Risk & Reproductive Outcomes
Investigating how vaginal microbiome dysbiosis increases HIV acquisition risk and affects reproductive health outcomes including preterm birth.
Active
Environmental Microbiome Water, Soil & Agriculture
Mapping microbial diversity in water sources, agricultural soil, and food systems to understand environmental transmission of pathogens.
Active
Early Life Microbiome Infant Development & Immunity
Studying how early-life microbiome establishment shapes immune development, nutritional status, and long-term health in African children.
Emerging
Microbiome-Based Therapeutics Probiotic & Intervention Studies
Evaluating microbiome modulation strategies including probiotics and dietary interventions to improve health outcomes in African populations.
Emerging
// Working With

Research &
Partner Network

Bioinformatics Unit

Developing metagenomic analysis pipelines and supporting large-scale microbial diversity studies.

Immunology Unit

Integrating microbiome data with immune profiling to understand host-microbe interactions and infection susceptibility.

Women's Health Unit

Collaborating on vaginal microbiome studies linking microbial health to HIV risk and reproductive outcomes.

African Microbiome Project

The broader consortium driving continent-wide microbiome research, data sharing, and African-led scientific leadership.

// The People

Meet the
Team

Prof. Thulani Makhalanyane
Prof. Thulani Makhalanyane

SARChI Chair in African Microbiome Innovation

// Research Output

Latest
Publications

No publications found.