CERI Research Focus Areas One Health
06

One Health
Research

One Health

Examining how human, animal, and environmental systems interact to shape disease emergence, antimicrobial resistance, and outbreak risk — identifying early warning signals and supporting multisectoral strategies for epidemic prevention.

Zoonotic Diseases
AMR
Ecological Drivers
Early Warning
Multisectoral
One Health Interface
Integrated Approach
Human
Health Systems
Animal
Veterinary & Wildlife
Environment
Ecology & Climate
Zoonotic Spillover
·
AMR Spread
·
Eco-epidemiology
Zoonotic Risk Monitoring
84%
AMR Cross-Species
76%
Environmental Surveillance
68%
3
Domains Integrated
15+
African Countries
80+
Publications
// Research Focus

What the Team
Investigates

FOCUS · 01
Zoonotic Transmission

Studying how pathogens cross from animals to humans, characterising spillover events, and identifying the ecological and behavioural drivers of zoonotic emergence.

Spillover Wildlife Livestock
FOCUS · 02
AMR Across Species

Investigating the spread of antimicrobial resistance genes across human, animal, and environmental reservoirs through integrated genomic surveillance.

AMR Genes Plasmids Agriculture
FOCUS · 03
Ecological Drivers of Epidemics

Examining how land use change, deforestation, climate variability, and biodiversity loss create conditions for pathogen emergence and epidemic risk.

Land Use Climate Biodiversity
FOCUS · 04
Environmental Pathogen Surveillance

Monitoring pathogens in water, soil, and food systems as early warning signals for outbreak risk and antimicrobial contamination.

Wastewater Water Quality Soil
FOCUS · 05
Early Warning Systems

Developing integrated surveillance frameworks that combine animal, environmental, and human health signals to detect outbreak threats before they escalate.

Surveillance Early Warning Preparedness
FOCUS · 06
Multisectoral Strategies

Engaging veterinary, agricultural, environmental, and human health sectors to co-develop sustainable epidemic prevention and AMR response strategies.

Policy Intersectoral Prevention
// Research Workflow

From Ecosystem
to Intervention

STEP · 01
Field Surveillance

Collecting samples from humans, animals, and environments across diverse ecosystems including wildlife habitats, farms, and water sources.

STEP · 02
Genomic Characterisation

Sequencing pathogens and AMR genes from multi-species samples to identify shared strains and track cross-species transmission events.

STEP · 03
Integrated Analysis

Combining genomic, ecological, and epidemiological data to map transmission networks across the human-animal-environment interface.

STEP · 04
Risk Assessment

Identifying high-risk interfaces, hotspots, and sentinel species that signal emerging threats for human populations.

STEP · 05
Prevention & Policy

Translating findings into multisectoral prevention strategies, early warning systems, and evidence-based policy for epidemic preparedness.

// Research Themes

Key Areas of
Investigation

Zoonotic Emerging Viruses Spillover Detection & Characterisation
Monitoring wildlife, livestock, and human populations for novel zoonotic pathogens with pandemic potential at high-risk interfaces in Africa.
Active
AMR in Agriculture Livestock, Soil & Water Contamination
Surveying AMR gene reservoirs in agricultural settings including livestock, poultry, aquaculture, and soil to understand environmental spread.
Active
Wastewater Epidemiology Environmental Pathogen Monitoring
Using wastewater surveillance as a community-level early warning system for infectious disease outbreaks and AMR circulation.
Active
Climate & Outbreak Risk Ecological Change & Disease Emergence
Modelling how climate change, deforestation, and habitat fragmentation alter vector ranges and zoonotic spillover risk across Africa.
Emerging
Wildlife Surveillance Sentinel Species & Hotspot Monitoring
Using wildlife as sentinel species to detect novel pathogens and monitor AMR at the human-animal interface in high-risk ecosystems.
Active
// Working With

Research &
Partner Network

AMR Research

Joint surveillance of AMR genes across human, animal, and environmental reservoirs using integrated genomic approaches.

Genomics Unit

Sequencing pathogens from multi-species samples to identify shared strains and track zoonotic transmission events.

Agricultural Partners

Collaborating with veterinary and agricultural institutions to survey AMR and pathogen circulation in food production systems.

FAO / WHO / WOAH

Contributing to tripartite One Health frameworks and continental AMR action plans through shared surveillance and policy support.

// The People

Meet the
Team

Prof Carla Mavian
Prof Carla Mavian

Senior Researcher and Programme Director: One Health Research

// Research Output

Latest
Publications

2026
CholeraSeq: a comprehensive genomic pipeline for cholera surveillance and near real-time outbreak investigation

Tagliamonte M, Sharma A, Riva A, Moir M, Salemi M, Baxter C,…

Bioinformatics 42

2025
Identifying genomic surveillance gaps in Africa for the global public health response to West Nile virus: a systematic review

Moir M, Sitharam N, Hofstra L, Dor G, Mwanyika G, Ramphal Y,…

The Lancet Microbe 6:101176

2025
CholeraSeq: a comprehensive genomic pipeline for cholera surveillance and near real-time outbreak investigation

Tagliamonte M, Sharma A, Riva A, Moir M, Salemi M, Baxter C,…

Bioinformatics 42

2025
Genomic Surveillance of Climate-Amplified Cholera Outbreak, Malawi, 2022–2023

Chabuka L, Choga W, Mavian C, Moir M, Morgenstern C, Tegaly H,…

Emerging Infectious Diseases 31(6):. doi: 10.3201/eid3106.240930.